UltraShear™ Technology (UST™) is a revolutionary high-pressure nanoemulsification homogenization system developed by Pressure BioSciences, Inc. (OTC Expert Market: PBIO). It is designed to produce long-term stable, oil-in-water nanoemulsions — vanishingly tiny droplets of oil dispersed in water, typically below 100 nanometers in diameter (like cellular components or viruses, and smaller than bacteria). UST has profound implications for enhancing the absorption and bioavailability of oil-based supplements, active pharmaceutical ingredients (APIs), and many other oil-based active ingredients (e.g., cosmeceuticals, agrochemicals, food & beverage) that typically present significant absorption challenges when delivered orally.
Let’s take a look at the science behind the revolutionary performance of UST nanoemulsions and examine the technology’s potential to reshape and improve the way supplements, APIs, and many other oil-based ingredients are delivered.
The Problem
Oil-based supplements and active ingredients—think fat-soluble vitamins (like D, E, A, and K), omega-3, CBD, and many therapeutic drugs — are typically dissolved in other natural food/plant oils as a carrier, and they intrinsically struggle with poor solubility in water (we all know oil and water don’t mix or stay mixed well).The result is that the oil remains in relatively large oil droplets that are not easily absorbable in our bodies and most of it passes quickly through our GI tract to be excreted. A vast and diverse array of ingredients beckon as opportunities for improved products enabled by Pressure BioSciences’ new UltraShear platform.
So why not just create an oil-based delivery system for all of these active ingredients? Quite simply, our bodies are a water-based environment, and our built-in oil absorption mechanisms are not very efficient in delivering oil-based active ingredients into our circulating bloodstream. Numerous studies have found that many lipophilic (oil soluble) drugs and other active ingredients demonstrate poor oral bioavailability from oil-based formulations (in the 5 – 20% range). In these cases, the vast majority of the active ingredients are not absorbed into the bloodstream but are excreted from the body and wasted.
How UltraShear™ Solves the Problem
The key value of UltraShear-generated nanoemulsions lies in their ability to improve the bioavailability of lipophilic (oil-loving) molecules that are the “active ingredients” in products such as nutraceuticals, cosmeceuticals, food and beverages, and many other important products, including cannabinoids (like CBD and THC). Features and benefits of UST nanoemulsions include:
- Vanishingly tiny droplets: At less than 100 nm in size, UST nanoemulsion oil droplets no longer scatter light and literally vanish into the surrounding water. When ingested, they easily penetrate through mucous tissues in your mouth and GI tract, and present vastly increased surface area available for digestive enzymes, further enhancing absorption of the actives from the oil.They are so small that (in other applications) they easily penetrate through the ultra-tight inter-cellular gaps in your skin’s protective layers and in the blood brain barrier.
- Improved solubility: UST nanoemulsions at this tiny scale easily achieve long-term stability, making otherwise water-insoluble ingredients suitable for long commercial shelf lives before finally being ingested and absorbed within the body of the human or animal consumer.
- Faster and higher uptake: UST nanoemulsions facilitate rapid and reliably efficient absorption of active ingredients from the nanoemulsified oil droplets, with high concentrations achieved in blood plasma levels within the first few minutes.Cumulative plasma levels demonstrate extremely high efficiency in total oral/GI absorption of UST nanoemulsified actives versus other oral/GI preparations.
A recent independent investigation by a top US research group in health and wellness showed UST’s ability to significantly enhance the uptake of oil-based supplements, using oil-soluble cannabidiol (CBD) as an example. Study results showed greatly enhanced bioavailability via ingestion (four to five-fold greater) of UST-processed CBD absorbed and surviving through first pass metabolism in the liver, compared to other processing methods. The CBD example from this study is illustrative of the greatly enhanced bioavailability that would be achievable with a broad array of other oil-based active ingredients. It is important to note that regardless of the baseline percentages for any given compound, a multi-fold increase in absorption is a profound, undeniable improvement over current non-UST processing methods.
Furthermore, the study highlighted the opportunities for achieving even higher blood plasma levels of actives that could be available via routes like spraying into the cheek (buccal route) or under the tongue (sublingual route).These routes deliver direct absorption through mucous tissues into the peripheral circulating bloodstream, avoiding first pass metabolism entirely and providing for much slower liver metabolism as portions of the circulating bloodstream eventually find their way through the liver.
The New UST-Based NanoSpray Product Line
Armed with this groundbreaking, patented technology, Pressure BioSciences is focusing on its UltraShear processing capabilities through PBIO’s new health & wellness division – Shear Sciences. The company is launching a line of breakthrough nanoemulsified products with revolutionary performance benefits, starting with its Super Antioxidant Oil Complex – Oral NanoSpray.
The Super Antioxidant NanoSpray contains a synergistic mixture of five nanoemulsified, highly popular antioxidant oils: Acai Berry Skin, Buah Merah Fruit, Medium-Chain Triglycerides (MCT), Pequi Fruit, and Sea Buckthorn Fruit.The NanoSpray is also infused with additional vitamins and supplements that have been reported to have significant antioxidant capabilities, including Omega-3 Fatty Acids, Coenzyme Q-10, Astaxanthin, Curcumin, Carotenoids, Lycopene, Mixed Tocopherols, and Vitamins A/C/D3/E/K2.
Consumer benefits include:
- Convenient, Easy-to-Use Oral Spray
- UST Nano for Rapid Absorption
- UST Nano for Unmatched Bioavailability
- All Natural (100% plant-based)
- Preservative-Free
- Sugar-Free (natural sweetener)
- Strawberry Flavor
Shear Sciences is launching its new UST-processed health and wellness product line with its Super Antioxidant Oil Complex – Oral NanoSpray leading the way. The company also has plans to use its patented UST platform to develop highly effective and efficacious pain, sleep, and cognitive enhancement NanoSpray products, as well as non-spray formats such as gummies.
The Commercial Potential
The ability to create rapidly absorbed, accurately dosed, long-term stable, and highly bioavailable nanoemulsions of oil-based ingredients for water-based systems (e.g., humans, animals, plants) has a broad range of applications, from nutraceutical supplements and cosmeceuticals, to agrochemicals, pharmaceuticals, and functional foods. Each of these categories offers multi-billion-dollar target markets for products with UST’s demonstrated capabilities.
In the United States alone, the dietary supplement market was estimated at about $64 billion last year and is projected to grow to $124 billion in the next eight years. A survey from 2019 found that 77% of U.S. adults take dietary supplements, and the trend is toward gummies and liquids rather than pills. It’s a fast-growing market and consumers are constantly searching for better and more efficient ways to achieve their health and wellness goals. Products created with the patented UltraShear nanoemulsification process are right on trend and offer the potential to completely transform how oil-based active ingredients are efficiently consumed.
Consumers interested in trying the all-natural, preservative-free, sugar-free, and highly bioavailable Super Antioxidant Oil Complex – Oral Nanospray can purchase the product here: www.shearsciences.com. Keep an eye out for future product releases at the same site. And please note that Pressure BioSciences is constantly looking for new ways to apply its groundbreaking technology to help improve your health and wellness.
